Alzheimer’s Disease: A Review

Posted: January 9, 2014 in Repeated Topics In PG Entrance
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  1. Alzheimer’s disease is the most common cause of dementia in the elderly. More than 5% of ≥70 year old persons in the world are affected from AD.
  2. AD most commonly presents with an insidious onset of memory loss followed by slowly progressing dementia over several years.
  3. Pathologically, atrophy is distributed throughout the medial temporal lobes, medial and lateral parietal lobes (temporo-parietal distribution) as well as, lateral frontal cortex.alzheimer_brain
  4. Microscopically, there are neuritic plaques containing neurofibrillary tangles (NFT) composed of hyperphosphorylated tau proteins and accumulation of amyloids in blood vessel walls of cortex and leptomeninges.plaques_and_tangles_border
  5. Brain scan is useful in diagnosing AD.




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