Muriform Bodies: Chromoblastomycosis

Posted: January 10, 2014 in Repeated Topics In PG Entrance
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  • Chromoblastomycosis is a chronic subcutaneous mycotic infection caused by saprophytic moulds ubiquitous in the environment.
  • The most common etiologic agents are Fonsecaea pedrosoi and Cladophialophora carrionii, both of which can be isolated from plant debris.
  • The infection usually follows traumatic inoculation through penetrating thorn or splinter wounds.
  • The fungal agents develop as small clusters of cells known as muriform bodies.

muriform body

  • Several months after the injury, painless papules or nodules appear in the affected area progressing to scaly and verrucose plaques.

verucous plaque in lower leg due to chromoblastomycosis

  • Direct examinations of skin scrapings or histopathologic study demonstrate the typical muriform bodies.
  • Microbiologic culture is necessary for the correct determination of the etiologic agent.
  • Itraconazole is the treatment of choice, often in combination with surgery.
  • Even so, results are often unsatisfactory as patients present late to medical services because of lack of funds and the fact that the disease usually affects the main family earner.
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